It is prospectively associated with the development of cardiovascular events in patients with diabetes, renal or cardiovascular disease, and it predicts diabetes, cardiovascular disease, and mortality in the general population. Various studies have shown that SAF is a useful marker of disease processes associated with oxidative stress. The AGE Reader has been developed to assess skin autofluorescence (SAF) non-invasively using the fluorescent properties of several AGEs. Measurement of AGEs in tissue such as skin requires invasive skin biopsies. AGEs have been implicated in various acute, and chronic diseases, stressing the need for reliable and comprehensive measuring techniques. These compounds may become systemically elevated in disease states, and accumulate in tissue, especially on long-lived proteins. Advanced glycation endproducts (AGEs) are sugar-modified adducts which arise during non-enzymatic glycoxidative stress.
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